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KMID : 0370220080520050402
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Yakhak Hoeji
2008 Volume.52 No. 5 p.402 ~ p.406
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1-Furan-2-yl-3-Pyridine-2-yl-Propenone Inhibits TNF-α-induced Intestinal Inflammation via Suppression of MCP-1 and IL-8 Expressions in HT-29 Human Colon Epithelial Cells
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Kim Kyoung-Jin
Kim Jong-Tae
Lee Eung-Seok
Lee Jong-Suk
Kim Jung-Ae
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Abstract
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Previously, we have shown that 1-furan-2-yl-3-pyridin-2-yl-propenone (FPP-3) has an anti-inflammatory activity
in a rat paw-edema model. In the present study, we investigated an inhibitory effect of FPP-3 on the tumor necrosis factor
(TNF)-??-induced inflammatory cytokine response in HT-29 human colon epithelial cells. Treatment with FPP-3 significantly prevented the TNF-??-induced attachment of leukocytes to HT-29 colon epithelial cells, which is one of the pathologic hallmarks in colon inflammation. The effect of FPP-3 was markedly superior than that of 5-aminosalicylic acid (5-ASA), a commonly used drug for the treatment of inflammatory bowel disease (IBD). The pretreatment with FPP-3 inhibited TNF-??- induced monocyte chemoattractant protein (MCP)-1, interleukin (IL)-8 mRNA expressions. In addition, FPP-3 significantly suppressed TNF-??-induced nuclear factor (NF)-B transcription activity. These results demonstrate that FPP-3 modulates intestinal inflammation via suppressing the NF-B dependent expressions of MCP-1 and IL-8, and suggest that FPP-3 may be a valuable agent for the treatment of IBD.
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KEYWORD
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1-furan-2-yl-3-pyridin-2-yl-propenone, inflammatory bowel disease, monocyte chemoattractant protein-1, interleukin-8, 5-aminosalicylic acid
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